Designed specifically for biologists, GeneSpring offers an interactive visualization and computing environment that promotes investigation and enables understanding of transcriptomics, genomics, metabolomics, and proteomics data within a biological context. GeneSpring is a data visualization and statistical analysis tool used by biologists for research and drug discovery. The NIH Libraryís GeneSpring license covers analysis of data from microarrays, qPCR, and NGS, and enables a user to examine probes across data types, array platforms, and organisms that map to the same biological entity. GeneSpring includes GO, GSEA/GSA, and pathway analysis with interaction databases for over 20 model organisms. The morning session of this class will provide an introduction to GeneSpring 14.5 and highlight new features. The afternoon Tips and Tricks session will be devoted to practical applications of GeneSpring using a TCGA cancer dataset.